Ritodrine HCl
A to Z Drug Facts
Ritodrine HCl |
(RIH-toe-dreen HIGH-droe-KLOR-ide) |
Ritodrine HCl, Ritodrine HCl in 5% Dextrose, Yutopar, Yutopar |
Class: Uterine relaxant |
Action Inhibits contractility of uterine smooth muscle through beta-adrenergic receptor stimulation.
Indications Management of preterm labor in suitable patients.
Contraindications Before 20th wk of pregnancy and when continuation of pregnancy is hazardous to mother or fetus; hypersensitivity; pre-existing maternal conditions that would be seriously affected by pharmacologic properties of betamimetic agent.
ADULTS: IV 0.05 mg/min initially, increasing by 0.05 mg/min q 10 min until desired result is obtained. The usual effective dose is between 0.15 to 0.35 mg/min, continued for at least 12 hr after uterine contractions cease.
Atropine: Systemic hypertension may be exaggerated. Beta-adrenergic blockers: Effects are antagonistic; avoid coadministration. Corticosteroids: Concomitant use may lead to pulmonary edema. Magnesium sulfate; diazoxide; meperidine; general anesthetics: Cardiovascular effects of ritodrine may be potentiated. Sympathomimetics: Effects may be additive or potentiated.
Lab Test Interferences None well documented.
CV: Palpitations; chest pain or tightness; heart murmur; angina pectoris; myocardial ischemia; alterations in BP; pulmonary edema; sinus bradycardia upon drug withdrawal; arrhythmias; drowsiness; weakness; mild tachycardia. CNS: Tremor, headache (including migraines); nervousness; jitteriness; restlessness; emotional upset; anxiety; malaise; hyperventilation. DERM: Erythema; rash GI: Nausea; constipation; diarrhea; vomiting; epigastric distress; ileus; bloating. HEMA: Leukopenia; agranulocytosis. HEPA: Hemolytic icterus; impaired liver function. META: Lactic acidosis; glycosuria. RESP: Dyspnea. OTHER: Sweating; chills; hypokalemia; hyperglycemia.
Pregnancy: Contraindicated before 20th wk of pregnancy; otherwise, Category B. Lactation: Undetermined. Cardiovascular responses: Are common and more pronounced with IV administration. Maternal pulmonary edema: Has been reported. Closely monitor and avoid fluid overload. Mild to moderate preeclampsia, hypertension or diabetes: Do not use in these patients unless benefits clearly outweigh risks. Advanced labor: Safety and efficacy in advanced labor (cervical dilation > 4 cm or effacement > 80%) are not established. Sulfite sensitivity: May cause allergic-type reaction in susceptible patients.
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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts