Ritodrine HCl

A to Z Drug Facts

Ritodrine HCl

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(RIH-toe-dreen HIGH-droe-KLOR-ide)
Ritodrine HCl, Ritodrine HCl in 5% Dextrose, Yutopar,  Yutopar
Class: Uterine relaxant

 Action Inhibits contractility of uterine smooth muscle through beta-adrenergic receptor stimulation.

 Indications Management of preterm labor in suitable patients.

 Contraindications Before 20th wk of pregnancy and when continuation of pregnancy is hazardous to mother or fetus; hypersensitivity; pre-existing maternal conditions that would be seriously affected by pharmacologic properties of betamimetic agent.

 Route/Dosage

ADULTS: IV 0.05 mg/min initially, increasing by 0.05 mg/min q 10 min until desired result is obtained. The usual effective dose is between 0.15 to 0.35 mg/min, continued for at least 12 hr after uterine contractions cease.

 Interactions

Atropine: Systemic hypertension may be exaggerated. Beta-adrenergic blockers: Effects are antagonistic; avoid coadministration. Corticosteroids: Concomitant use may lead to pulmonary edema. Magnesium sulfate; diazoxide; meperidine; general anesthetics: Cardiovascular effects of ritodrine may be potentiated. Sympathomimetics: Effects may be additive or potentiated.

 Lab Test Interferences None well documented.

 Adverse Reactions

CV: Palpitations; chest pain or tightness; heart murmur; angina pectoris; myocardial ischemia; alterations in BP; pulmonary edema; sinus bradycardia upon drug withdrawal; arrhythmias; drowsiness; weakness; mild tachycardia. CNS: Tremor, headache (including migraines); nervousness; jitteriness; restlessness; emotional upset; anxiety; malaise; hyperventilation. DERM: Erythema; rash GI: Nausea; constipation; diarrhea; vomiting; epigastric distress; ileus; bloating. HEMA: Leukopenia; agranulocytosis. HEPA: Hemolytic icterus; impaired liver function. META: Lactic acidosis; glycosuria. RESP: Dyspnea. OTHER: Sweating; chills; hypokalemia; hyperglycemia.

 Precautions

Pregnancy: Contraindicated before 20th wk of pregnancy; otherwise, Category B. Lactation: Undetermined. Cardiovascular responses: Are common and more pronounced with IV administration. Maternal pulmonary edema: Has been reported. Closely monitor and avoid fluid overload. Mild to moderate preeclampsia, hypertension or diabetes: Do not use in these patients unless benefits clearly outweigh risks. Advanced labor: Safety and efficacy in advanced labor (cervical dilation > 4 cm or effacement > 80%) are not established. Sulfite sensitivity: May cause allergic-type reaction in susceptible patients.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
  Symptoms relate to excessive betaadrenergic stimulation and include tachycardia, palpitations, cardiac arrhythmias, hypotension, dyspnea, nervousness, tremor, nausea, vomiting

 Patient/Family Education

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Copyright
© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts